pISSN : 2383-6415   eISSN : 2383-6423

Effect of Dietary Soybean Protein on Cerebral Infarction Size and Antioxidant Enzyme Activities in Rat Focal Brain Ischemia Model



INFORMATION : page. 1~10 / 2008 Vol.10 No.1


Purpose: The purpose of this study was to investigate the cerebral infarction size, antioxidant enzyme activities and lipid peroxidation changes after 6 weeks of dietary soybean protein intake in a rat focal brain ischemia model. Method: Weaning Sprague-Dawley rats were fed with either modified AIN-93G diet containing casein 20% (control), 20% soybean protein isolate-based diet (S20), or 40% of soybean protein isolate-based diet (S40) for 6 weeks. The animals were subject to right middle cerebral artery occlusion for 2 hr. After 24 hr of recirculation, the rats were sacrificed. Antioxidant enzymes activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and thiobarbituric acid reactive substance (TBARS) level in the right brain were also measured. Result: There were no significant differences in the right cortical infarction volume, TBARS level, SOD and CAT activities among the three groups whereas the GPx activities of the S20 group were significantly higher than those of the control group (p=.02). Conclusion: Our results suggest that 20% of soybean protein may have a modulating effect on GPx and possibly have some protective effect against oxidative stress although it may enough to decrease cerebral infarction volume in rat focal brain ischemia model.

Keyword :

대두 단백질,뇌경색,Soybean protein,Cerebral infarction,TBARS (Thiobarbituric acid reactive substance),SOD (Superoxide dismutase),GPx (Glutathione peroxidase)


Journal Archive

21 Volumes, 3 Issues, 489 Articles

show all

Tag Cloud

항암화학요법 골아세포 Self efficacy Physical function 인식 Children

Korean Society of Biological Nursing Science (Stay Connected)
Department of Nursing, Chungbuk National University, 1 Chungdae-ro, Seowon-Gu, Cheongju, Chungbuk, 28644, Republic of Korea
Tel : +82-43-249-1860 (Contact JKBNS Customer care: bionursing@naver.com) http://www.bionursing.or.kr/
Copyright JKBNS. All Rights Reserved.
Design by Hakjisa Pub.